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TD139
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TD139图片
CAS NO:1450824-22-2
规格:98%
分子量:648.64
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议
500mg电议
1g电议

产品介绍
TD139 is an inhaled galectin-3 inhibitor with a Kd of 14 nM.
CAS:1450824-22-2
分子式:C28H30F2N6O8S
分子量:648.64
纯度:98%
存储:Store at -20°C

Background:

TD139 is an inhaled galectin-3 inhibitor with a Kd of 14 nM.


TD139 is a novel synthetic inhibitor of galectin-3. TD139 has high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N[1].


In primary lung AECs TD139 reduces TGF-β1-induced β-catenin translocation to the nucleus, with most of the β-catenin remaining at the cell surface. TD139 blocks TGF-β1-induced β-catenin phosphorylation. A marked reduction in fibrosis and β-catenin activation accompanied by decreased galectin-3 expression is observed in the lungs of WT mice treated with TD139[1]. Pretreatment of WT C57BL/6 mice with TD139 leads to the attenuation of liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, as well as an increase in the total number of IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activates macrophages and preventes the apoptosis of liver-infiltrating MNCs[2].


参考文献:
[1]. Mackinnon AC, et al. Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46.
[2]. Volarevic V, et al. Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology. 2012 Jun;55(6):1954-64.