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AF38469
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AF38469图片
CAS NO:1531634-31-7
规格:98%
分子量:324.25
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.
CAS:1531634-31-7
分子式:C15H11F3N2O3
分子量:324.25
纯度:98%
存储:Store at -20°C

Background:

AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.


AF38469 showed no inhibition or stimulation of >50% at 10 uM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate evaluation of the therapeutic potential of this protein[1].


参考文献:
[1]. Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80.