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MBM-17
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MBM-17图片
CAS NO:2083621-90-1
规格:98%
分子量:480.56
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
MBM-17 (compound 42c) 是有效的 NIMA-related kinase 2 (Nek2) 抑制剂,IC50 值为 3 nM,通过诱导细胞周期停滞和凋亡,抑制癌细胞的增殖,具有抗肿瘤活性,且对小鼠没有明显的毒性。
CAS:2083621-90-1
分子式:C28H28N6O2
分子量:480.56
纯度:98%
存储:Store at -20°C

Background:

MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. IC50: 3 nM (Nek2), 5800 nM (Aurora A)[1]


MBM-17 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively[1].



[1]. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.