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AX20017
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AX20017图片
CAS NO:329221-38-7
规格:98%
分子量:264.34
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
AX20017是蛋白激酶G(PknG)的小分子抑制剂,IC50值为0.39μM。
CAS:329221-38-7
分子式:C13H16N2O2S
分子量:264.34
纯度:98%
存储:Store at -20°C

Background:

AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM.


The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017[2].AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis[3].



[1]. Walburger A, et al. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4. [2]. Santhi N, et al. Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis. Bioinformation. 2011;7(1):1-4. [3]. Scherr N, et al. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12151-6.