IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells.
CAS：861891-50-1
分子式：C19H23N3O2
分子量：325.4
纯度：98%
存储：Store at -20°C

Background:

IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells. It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase [1]

Reference：
[1]. Dodo, K., Katoh, M., Shimizu, T., et al. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. Bioorganic & Medicinal Chemistry Letters 15(12), 3114-3118 (2005).