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E-4031 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
E-4031 dihydrochloride图片
CAS NO:113559-13-0
规格:98%
分子量:474.44
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
KV11.1 (hERG) channels blocker
CAS:113559-13-0
分子式:C21H27N3O3S.2HCl
分子量:474.44
纯度:98%
存储:Store at -20°C

Background:

E-4031?is a class III antiarrhythmic agent?which selectively blocks?hERG?potassium channel.


参考文献:
[1]. Nalos L, et al. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol. 2012 Jan;165(2):467-78.
[2]. Verheijck EE, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76(4):607-15.
[3]. Izumi-Nakaseko H, et al. Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs. Eur J Pharmacol. 2014 Oct 5;740:263-70.
[4]. Izumi D, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33(8):950-9.