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Bosutinib(SKI-606)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bosutinib(SKI-606)图片
CAS NO:380843-75-4
规格:98%
分子量:530.45
包装与价格:
包装价格(元)
5mg电议
100mg电议

产品介绍
Potent Abl/Src kinases
CAS:380843-75-4
分子式:C26H29Cl2N5O3
分子量:530.45
纯度:98%
存储:Store at -20°C

Background:

Bosutinib (SKI-606) is a potent inhibitor of Src and Abl kinases with IC50 of 1.2 nM and 1 nM [1].


In chronic myelogenous leukemia (CML) cells, SKI-606 inhibited phosphorylation of Bcr-Abl, Src and Stat5. It also ablated the expression of v-Abl in fibroblasts and blocked proliferation of CML cells [2]. In colorectal cancer cells, SKI-606 inhibited Src autophosphorylation with an IC50 of