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RJR-2403 oxalate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RJR-2403 oxalate图片
CAS NO:220662-95-3
规格:98%
分子量:252.27
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Nicotinic receptor agonist
CAS:220662-95-3
分子式:C12H16N2O4
分子量:252.27
纯度:98%
存储:Store at -20°C

Background:

Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); >1,000 fold selectivity than α7 receptors(Ki= 3.6 μM).


参考文献:
[1]. Bencherif M, et al. RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.
[2]. Lippiello PM, et al. RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.
[3]. Damaj MI, et al. Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.