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Pemetrexed
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pemetrexed图片
CAS NO:150399-23-8
规格:98%
分子量:471.37
包装与价格:
包装价格(元)
100mg电议
200mg电议

产品介绍
TS, DHFR,GARFT and AICARFT inhibitor
CAS:150399-23-8
分子式:C20H19N5Na2O6
分子量:471.37
纯度:98%
存储:Store at -20°C

Background:

Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis. Pemetrexed is an analog of the classic antifolate GARFYT inhibitor lometroxol with a similar chemical structure, where the pyrazine ring in the pterine portion of folic acid and the benzylic nitrogen in the bridge portion of folic acid are replaced by a pyrrole ring and a methylene group respectively. Pemetrexed potently inhibits TS, DHFR, and GARFT as well as AICARFT but with a lesser potency and exhibits autitumor activity in a broad range of tumors, including non-small cell lung carcinoma, malignant mesothelioma, and carcinomas of the breast, colorectum, uterine cervix, head and neck, and bladder.


Reference


[1].Luis Paz-Ares, Susana Bezares, Jose M. Tabernero, Daniel Castellanos, and Hernan Cortes-Funes. Review of a promising new agent-pemetrexed disodium. Cancer 2003; 97(8 Suppl):2056-2063