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β-Amyloid(1-42),rat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:166090-74-0
规格:98%
分子量:4418.02
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
β-Amyloid (1-42), rat 是由 42 个氨基酸组成的多肽,对海马切片有毒性,可用于阿尔兹海默症的研究。
CAS:166090-74-0
分子式:C199H307N53O59S
分子量:4418.02
纯度:98%
存储:Store at -20°C

Background:

β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer’s disease. Amyloid-β[1]


β-Amyloid (1-42), rat shows cytotoxic effect on the hippocampal slices at 20 μM[1]. β-Amyloid (1-42), rat causes morphological changes in NGF-induced PC12 cells, induces formed cell processes to retract in differentiated cells and affect the expression of exons 2/3 in both undifferentiated and differentiated cells[2].



[1]. Mozes E, et al. A novel method for the rapid determination of beta-amyloid toxicity on acute hippocampal slices using MTT and LDH assays. Brain Res Bull. 2012 Apr 10;87(6):521-5. [2]. Lagunes T, et al. Abeta(1-42) induces abnormal alternative splicing of tau exons 2/3 in NGF-induced PC12 cells. An Acad Bras Cienc. 2014 Dec;86(4):1927-34.