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Sacubitril sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sacubitril sodium图片
CAS NO:149690-05-1
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
Sacubitril sodium (also known as AHU-377), the sodium salt of Sacubitril, is an NEP (neutral endopeptidase 24.11) inhibitor (IC50 = 5 nM) used as a component of the heart failure medicine LCZ696 (LCZ-696; LCZ 696; Entresto; Sacubitril mixture with Valsartan). As a prodrug, Sacubitril has to be activated to LBQ-657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.
理化性质和储存条件


ame: Sacubitril sodium
CAS#: 149690-05-1 (sodium)
Chemical Formula: C24H28NNaO5
Molecular Weight: 433.4798
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical Information

Synonym: AHU377 sodium; LCZ696; AHU 377; LCZ 696; AHU-377; LCZ69

6Chemical Name: sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate

InChi Key: RRTBVEJIZWGATF-JKSHRDEXSA-M
InChi Code: InChI=1S/C24H29NO5.Na/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;+1/p-1/t17-,21+;/m1./s1
SMILES Code: O=C([O-])CCC(N[C@@H](C[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O.[Na+]