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LAS-31180
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LAS-31180图片
CAS NO:137338-43-3
规格:98%
分子量:252.29
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
LAS-31180是一种phosphodiesterase3的抑制剂,能够增强肌肉收缩和血管舒张。
CAS:137338-43-3
分子式:C11H12N2O3S
分子量:252.29
纯度:98%
存储:Store at -20°C

Background:

LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.


LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1].


In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].


[1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.