Background:

Sucrose is a disaccharide which is composed of two monosaccharides, glucose and fructose.

Sucrose is a disaccharide which is composed of two monosaccharides, glucose and fructose. Compare to chow-feeding, high-energy (HE)-feeding results in an overall decreased preference for Sucrose solutions in both strains. Specifically, obesity-prone (OP) rats prefer 0.3 M and 1.0 M Sucrose solutions less during HE-feeding relative to chow-feeding (P=0.046 and P=0.012, respectively). As well, obesity-resistant (OR) rats exhibit decreased preferences for 0.01 M, 0.03 M, and 1.0 M Sucrose when HE-fed compare to chow-fed counterparts (P<0.0001, P=0.043, and P=0.013, respectively). Chow-fed OP rats consume significantly less of 0.03 and 0.1 M Sucrose solutions relative to OR animals (P<0.0001, for both) while HE-fed OP rats consume less of a 0.1 M Sucrose solution only (P<0.05), compare to HE-fed OR rats[1].

[1]. Duca FA, et al. Effect of diet on preference and intake of sucrose in obese prone and resistant rats. PLoS One. 2014 Oct 20;9(10):e111232.