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PF-06747711
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-06747711图片
CAS NO:1892576-58-7
包装:5mg
规格:98%
市场价:2517元
分子量:497.51

产品介绍
PF-06747711是一种有效、选择性、可口服的视黄酸受体相关孤儿受体C2(RORC2或RORγt)的反向激动剂,IC50值为4.1nM。具有抗皮肤炎的功效。
CAS:1892576-58-7
分子式:C26H26F3N5O2
分子量:497.51
纯度:98%
存储:Store at -20°C

Background:

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity[1]. IC50: 4.1 nM (RORC2)[1]


PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC50 of 9.5 nM[1].


PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice[1]. Animal Model: 8-10 week old female Balb/c mice[1]


[1]. Schnute ME, et al. Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist. J Med Chem. 2018 Sep 9.