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β-Melanocyte Stimulating Hormone(MSH),human(Beta-MSH(1-22)(human))
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:17908-57-5
规格:98%
分子量:2660.92
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
β-MelanocyteStimulatingHormone(MSH),human是黑皮质素受体(melanocortin(MC)receptor)激动剂。
CAS:17908-57-5
分子式:C118H174N34O35S
分子量:2660.92
纯度:98%
存储:Store at -20°C

Background:

β-Melanocyte Stimulating Hormone (MSH), human is a melanocortin (MC) receptor agonist.


β-Melanocyte Stimulating Hormone is a powerful anti-inflammatory agent which effect is brought by activation of the central MC3/MC4 receptors and thereby inhibits NO production by inhibiting the translocation of transcription factor NF-κB to the nuclei of the brain cells and decreasing iNOS expression[1]. β-Melanocyte Stimulating Hormone has significantly higher at human MC4-R transfected into CHO cells (Ki=11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (Ki=22.5±2.3 nM)[2].


β-Melanocyte Stimulating Hormone suppresses LPS-induced nuclear translocation of the transcription factor NF-κB, and inhibits the expression of inducible nitric oxide synthase, and the following nitric oxide overproduction in the brain[1].β-Melanocyte Stimulating Hormone is a key ligand at the MC4-R populations that regulate feeding, and that inhibition of tonic release of β-MSH is one mechanism contributing to hunger in under-feeding[2].


[1]. Muceniece R, et al. Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling. J Neuroimmunol. 2005 Dec;169(1-2):13-9. [2]. Harrold JA, et al. beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R? Peptides. 2003 Mar;24(3):397-405.