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ONO4057(ONO-LB457)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ONO4057(ONO-LB457)图片
CAS NO:134578-96-4
规格:98%
分子量:470.55
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
ONO4057是LeukotrieneB4受体的拮抗剂,其IC50值为0.7±0.3μM。
CAS:134578-96-4
分子式:C27H34O7
分子量:470.55
纯度:98%
存储:Store at -20°C

Background:

ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM.



Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group[2].


[1]. Kishikawa K, et al. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75. [2]. Tanaka M, et al. Effect of leukotriene B(4) receptor antagonist (ONO4057) on hepatic allografting in rats. Transplant Proc. 2000 Nov;32(7):2340.