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FPS-ZM1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FPS-ZM1图片
CAS NO:945714-67-0
规格:98%
分子量:327.9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
RAGE Inhibitor
CAS:945714-67-0
分子式:C20H22ClNO
分子量:327.9
纯度:98%
存储:Store at -20°C

Background:

Ki: 25 nM


FPS-ZM1 is a RAGE Inhibitor.


The receptor for advanced glycation end products (RAGE) belongs to the immunoglobulin superfamily. RAGE has an extracellular V domain binding multiple ligands. The ligand-RAGE interactions result in sustained cellular perturbation in chronic diseases including diabetes, inflammation, as well as AD.


In vitro: FPS-ZM1 was identified as a high-affinity inhibitor of the receptor for advanced glycation end products. FPS-ZM1 could block the binding of amyloid β (Aβ) protein to RAGE and inhibit Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells [1].


In vivo: Animal study found that FPS-ZM1 was nontoxic to mice and readily crossed the blood-brain barrier (BBB). In aged APPsw/0 mice overexpressing human Aβ-precursor protein, FPS-ZM1 could inhibit RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain. FPS-ZM1 bound exclusively to RAGE In brain, which inhibited β-secretase activity and Aβ production and suppressed microglia activation and the neuroinflammatory response. Moreover, the blockade of RAGE actions at the BBB and in the brain could reduce Aβ40 and Aβ42 levels in brain in aged APPsw/0 mice [1].


Clinical trial: So far, no clinical study has been conducted.


Reference:
[1] Deane, R. ,Singh, I.,Sagare, A.P., et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J. Clin. Invest. 122(4), 1377-1392 (2012).