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SP187(MON-DNJ)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SP187(MON-DNJ)图片
CAS NO:615253-61-7
规格:98%
分子量:319.44
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
SP187是一种靶向作用于宿主的针对丝状病毒感染的亚胺糖。SP187在体内抗流感和登革热。
CAS:615253-61-7
分子式:C16H33NO5
分子量:319.44
纯度:98%
存储:Store at -20°C

Background:

SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.


The antiviral activity of iminosugar SP187 (UV-4) in vitro against EBOV and MARV is assessed using a yield-plaque assay format and the IC50 is determined. Antiviral activity for SP187 is observed with IC50 of 29.97 and 47.72 μM for EBOV and MARV, respectively[1].


The efficacy of SP187 (UV-4), the active free base component of UV-4B, and UV-5, the most potent iminosugar tested in vitro, is first assessed using a mouse model of EBOV infection. In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started