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Litronesib(LY-2523355)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Litronesib(LY-2523355)图片
CAS NO:910634-41-2
规格:98%
分子量:511.7
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Litronesib是一种选择性的Eg5抑制剂,具有抗肿瘤的活性。
CAS:910634-41-2
分子式:C23H37N5O4S2
分子量:511.7
纯度:98%
存储:Store at -20°C

Background:

Litronesib is a selective Eg5 inhibitor, with antitumor activity.


Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC)[1].


Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].


[1]. Ye XS, et al. A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models. Mol Cancer Ther. 2015 Nov;14(11):2463-72.