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CP-66948
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CP-66948图片
CAS NO:101189-47-3
规格:98%
分子量:292.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
CP-66948是histamineH2受体拮抗剂,能够抑制胃酸分泌,保护粘膜的作用。
CAS:101189-47-3
分子式:C13H20N6S
分子量:292.4
纯度:98%
存储:Store at -20°C

Background:

CP-66948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties.



The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously)[1].


[1]. Hakkinen JP, et al. CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties. Dig Dis Sci. 1991 Dec;36(12):1721-8.