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Efaproxiral Sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Efaproxiral Sodium图片
CAS NO:170787-99-2
包装:50mg
规格:98%
市场价:592元
分子量:363.38

产品介绍
Synthetic allosteric modifier of hemoglobin
CAS:170787-99-2
分子式:C20H23NO4.Na
分子量:363.38
纯度:98%
存储:Store at -20°C

Background:

Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.


参考文献:
[1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784.