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Nisin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nisin A图片
CAS NO:1414-45-5
规格:98%
分子量:3354.1
包装与价格:
包装价格(元)
1g电议
5g电议
10g电议

产品介绍
antibacterial peptide
CAS:1414-45-5
分子式:C143H230N42O37S7
分子量:3354.1
纯度:98%
存储:Store at -20°C

Background:

Nisin A is an antibacterial peptide.


Nisin A is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics.


In vitro: Previous study showed that the sperm motility could be completely inhibited with nisin A. The minimum effective concentration of nisin A required to immobilize sperm in vitro within 20 s was found to be 50 microg in rat, 200 microg in rabbit and 300-400 microg in monkey and human. Such inhibitory effect on sperm motility was found to be dose- and time-dependent [1].


In vivo: Intravaginal administration of nisin A before mating during proestrus-estrous transition phase caused complete arrest of sperm motility and blockage of conception. Subacute toxicity studies in rats showed that, repetitive intravaginal application of nisin A at the dose of 200 microg for 14 days caused no abnormalities either in the length of estrous cycle or in the morphology of vaginal epithelial cells. Moreover, no histopathological abnormalities in vaginal tissue or any change in blood and serum biochemical profiles were seen. In addition, no adverse effects were found on subsequent reproductive performance, development of pups and neonate survival [1].


Clinical trial: Up to now, nisin A is still in the preclinical development stage.


Reference:
[1] Aranha C, Gupta S, Reddy KV.  Contraceptive efficacy of antimicrobial peptide Nisin: in vitro and in vivo studies. Contraception. 2004 Apr;69(4):333-8.