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BNC105
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BNC105图片
CAS NO:945771-74-4
规格:98%
分子量:372.37
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
BNC105是一种具有抗增殖和破坏肿瘤血管功能的,微管蛋白聚合抑制剂。
CAS:945771-74-4
分子式:C20H20O7
分子量:372.37
纯度:98%
存储:Store at -20°C

Background:

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.




[1]. Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27. [2]. Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73. [3]. Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60.