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β-CGRP,human(Humanβ-CGRP)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:101462-82-2
规格:98%
分子量:3793.41
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
β-CGRP,human是一种降钙素肽,通过降钙素受体样受体CRLR与RAMP的复合物起作用,在细胞体系中,对CRLR/RAMP1和CRLR/RAMP2的IC50值分别为1nM和300nM。
CAS:101462-82-2
分子式:C162H267N51O48S3
分子量:3793.41
纯度:98%
存储:Store at -20°C

Background:

β-CGRP, human is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.


β-CGRP, human is one of calcitonin peptides, acts via complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 130 nM and 300 nM in NG108-15 and HEK293T cells expressing CRLR and RAMP2[1]. CGRP is a potent vasodilator and also shows pro- and -anti-inflammatory activity[2].



[1]. McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. [2]. Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142.