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Afegostat D-Tartrate(D-Isofagomine(D-Tartrate))
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Afegostat D-Tartrate(D-Isofagomine(D-Tartrate))图片
CAS NO:957230-65-8
规格:98%
分子量:297.26
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
AfegostatD-Tartrate是一种药理学伴侣,高亲和力且特异性和可逆地结合内质网(ER)中的酸性β-葡萄糖苷酶(GCase)。
CAS:957230-65-8
分子式:C10H19NO9
分子量:297.26
纯度:98%
存储:Store at -20°C

Background:

Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].



Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1].


[1]. Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11(4):840-56.