您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Maytansinol(Ansamitocin P-0)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Maytansinol(Ansamitocin P-0)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Maytansinol(Ansamitocin P-0)图片
CAS NO:57103-68-1
规格:98%
分子量:565.06
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
Maytansinol抑制微管组装且诱导微管解,与辐射联用,用于果蝇和人类癌细胞。
CAS:57103-68-1
分子式:C28H37ClN2O8
分子量:565.06
纯度:98%
存储:Store at -20°C

Background:

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug.




[1]. Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503.