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Digitonin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Digitonin图片
CAS NO:11024-24-1
包装:25mg
规格:98%
市场价:445元
分子量:1229.31

产品介绍
Digitonin是从洋地黄中提取的糖苷,可通过与胆固醇分子结合来增加细胞膜的通透性,并能抑制肿瘤生长。
CAS:11024-24-1
分子式:C??H??O??
分子量:1229.31
纯度:98%
存储:Store at -20°C

Background:

Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth.


Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro[1].


In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg[1].


Reference:


[1]. Lindnér PG, et al. Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration. Cancer Chemother Pharmacol. 1997;40(5):444-8.