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RS-601
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RS-601图片
CAS NO:207987-59-5
规格:98%
分子量:511.48
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
RS-601是有效的leukotrieneD4/thromboxaneA2双重抑制剂,具有平喘作用。
CAS:207987-59-5
分子式:C22H23F6NO4S
分子量:511.48
纯度:98%
存储:Store at -20°C

Background:

RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.



RS-601 (1-10 mg/kg) clearly inhibits the bronchoconstriction induced by intravenous administration of U-46619 and LTD4 in a dose-dependent fashion in guinea pigs. RS-1452 (10 mg/kg) significantly inhibits U-46619-induced bronchoconstriction, respectively. RS-601 significantly inhibits the late-phase response and LPS-induced AHR at a dose of 10 mg/kg, but does not affect biphasic bronchial responses. RS-601 (3 and 10 mg/kg) also clearly inhibits the AHR[1].


[1]. Yamada T, et al. Effects of RS-601, a novel leukotriene D(4)/thromboxane A(2) dual receptor antagonist, on asthmatic responses in guinea pigs. Pharmacology. 2003 Sep;69(1):51-8.