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Luteinizing Hormone Releasing Hormone(LH-RH),human
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Luteinizing Hormone Releasing Hormone(LH-RH),human图片
CAS NO:71447-49-9
规格:98%
分子量:1302.41
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
LuteinizingHormoneReleasingHormone(LH-RH),human是下丘脑神经肽,其在控制生殖功能中起关键作用。
CAS:71447-49-9
分子式:C55H75N17O13.2C2H4O2
分子量:1302.41
纯度:98%
存储:Store at -20°C

Background:

Luteinizing Hormone Releasing Hormone (LH-RH), human is hypothalamic neuropeptide which plays a key role in the control of reproductive functions.


Luteinizing Hormone Releasing Hormone (LH-RH), also called gonadotropin-releasing hormone (GnRH), is the primary link between the brain, the pituitary and gonadal function, and has a key role in vertebrate reproduction. The endocrine actions of Luteinizing Hormone Releasing Hormone (LH-RH) and its analogs are mediated by high-affinity membrane receptors for LHRH on pituitary gonadotrophs[1]. LHRH is expressed,together with its receptors,in hormonerelated tumors such as prostate cancer,to act as a local autocrine/paracrine growth inhibitory factor. In prostate cancer cells,the LHRH receptor is coupled to the Gi-cAMP pathway to inhibit cell proliferation[3].


Luteinizing Hormone Releasing Hormone treatment advances the timing of vaginal opening by 5 days, which is used as an initial indicator for the time of puberty[2].


[1]. Engel JB, et al. Drug Insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone. Nat Clin Pract Endocrinol Metab. 2007 Feb;3(2):157-67. [2]. Moretti RM, et al. Inhibitory activity of luteinizing hormone-releasing hormone on tumor growth and progression. Endocr Relat Cancer. 2003 Jun;10(2):161-7. [3]. Urbanski HF, et al. Activation of luteinizing hormone-releasing hormone release advances the onset of femalepuberty. Neuroendocrinology. 1987 Sep;46(3):273-6.