您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > O-Phospho-D-Serine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
O-Phospho-D-Serine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
O-Phospho-D-Serine图片
CAS NO:73913-63-0
规格:98%
分子量:185.1
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
weak agonist of the metabotropic glutamate receptor mGluR4
CAS:73913-63-0
分子式:C3H8NO6P
分子量:185.1
纯度:98%
存储:Store at -20°C

Background:

IC50: 1,260 μM for the metabotropic glutamate receptor mGluR4


O-Phospho-D-Serine is a weak agonist of the metabotropic glutamate receptor mGluR4.


mGluR4 receptors, a member of the G protein-linked family of receptors for glutamate, are negatively coupled to cAMP. Its expression is highest in granule cells of the cerebellum that send parallel fibers that synapse with Purkinje cell dendrites.


In vitro: The affinity of L-serine-O-phosphate was examined in a baby hamster kidney cells expressing subtype mGluR1 or mGluR4 of the mGluR family. Results showed that both L-serine-O-phosphate or O-Phospho-D-Serine at 3 mM did not inhibit PI-hydrolysis as stimulated by 10 μM glutamate in BHK cells expressing mGluR1. However, L-serine-O-phosphate was a potent agonist at the mGluR4 subtype, which was negatively coupled to adenylate cyclase, while O-Phospho-D-Serine was found to be weakly active [1]. In another study, to test whether phosphatidylserine was recognized by amebae, calcium-treated cells were incubated with annexin V prior to adherence to or ingestion by E. histolytica. It was found that the coreceptor could be inhibited by phospho-l-serine and to a lesser extent by O-Phospho-D-Serine but not by phospho-l-threonine, which was consistent with the coreceptor functioning in the adherence and ingestion of erythrocytes via recognition of phosphatidylserine [2].


In vivo: Up to now, there is no animal in vivo data reported.


Clinical trial: So far, no clinical study has been conducted.


参考文献:
[1] Thomsen, C. , and Suzdak, P.D. Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. NeuroReport 4, 1099-1101 (1993).
[2] Boettner, D. R.,Huston, C.D.,Sullivan, J.A., et al. Entamoeba histolytica and Entamoeba dispar utilize externalized phosphatidylserine for recognition and phagocytosis of erythrocytes. Infection and Immunity 73(6), 3422-3430 (2005).