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ST638
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ST638图片
CAS NO:107761-24-0
规格:98%
分子量:354.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
tyrosine kinase inhibitor and PLD inhibitor
CAS:107761-24-0
分子式:C19H18N2O3S
分子量:354.4
纯度:98%
存储:Store at -20°C

Background:

ST638 is a tyrosine kinase inhibitor [1].


Tyrosine kinases are a family of protein kinases that phosphorylate the serine and threonine on other proteins. Phosphorylation of proteins by kinases has been involved in signal transduction and regulating cellular activity, such as cell division. Tyrosine kinases function in a variety of processes, such as mitogenesis, induction of mitosis, and transmembrane signaling [2].


In human platelets, preincubation with 50 μM of ST638 completely blocked the platelet aggregation induced with 0.05 unit/ml of thrombin. ST638 inhibited the increase of protein-tyrosine phosphorylation bands induced with thrombin in a dose-dependent manner. ST638 blocked the platelet aggregation and protein-tyrosine phosphorylation induced with thrombin in aspirin-treated platelets [1]. In terminal erythroid differentiation of mouse erythroleukemia (MEL) cells, ST638 effectively induced differentiation in a synergistic manner [3]. In rat and rabbit pulmonary artery cells, ST 638 (0.5 to 40 μmol/L) blocked IK in a dose-dependent manner [4].


参考文献:
[1] Asahi M, Yanagi S, Ohta S, et al.  Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein[J]. FEBS letters, 1992, 309(1): 10-14.
[2] Levitzki A, Gazit A.  Tyrosine kinase inhibition: an approach to drug development[J]. Science, 1995, 267(5205): 1782.
[3] Watanabe T, Shiraishi T, Sasaki H, et al.  Inhibitors for protein-tyrosine kinases, ST638 and genistein, induce differentiation of mouse erythroleukemia cells in a synergistic manner[J]. Experimental cell research, 1989, 183(2): 335-342.
[4] Smirnov S V, Aaronson P I.  Inhibition of vascular smooth muscle cell K+ currents by tyrosine kinase inhibitors genistein and ST 638[J]. Circulation Research, 1995, 76(2): 310-316.