BI-9627是一种钠氢交换异构体1(NHE1)抑制剂,EC50值为31nM.
CAS:1204329-34-9
分子式:C16H19F3N4O2
分子量:356.34
纯度:98%
存储:Store at -20°C
Background:
BI-9627 is a sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor with an EC50 of 31 nM[1].
EC50: 31 nM (Sodium-hydrogen exchanger isoform 1)[1]
[1]. Huber JD, et al. Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitableprofile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J Med Chem. 2012 Aug 23;55(16):7114-40.