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UK-371804
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UK-371804图片
CAS NO:256477-09-5
规格:98%
分子量:385.83
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
UK-371804是尿嘧啶型纤溶酶原激活物(uPA)的抑制剂,Ki值为10nM。
CAS:256477-09-5
分子式:C14H16ClN5O4S
分子量:385.83
纯度:98%
存储:Store at -20°C

Background:

UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.


UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin)[1].


In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM[1].


[1]. Fish PV, et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51.