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TM-N1324
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TM-N1324图片
CAS NO:1144477-35-9
规格:98%
分子量:397.79
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
TM-N1324是G蛋白偶联受体39(GPR39)的激动剂,在Zn2+存在的情况下,对人和鼠GPR39的EC50值分别为9nM和5nM,在Zn2+不存在的情况下,对人和鼠GPR39的EC50值分别为280nM和180nM。
CAS:1144477-35-9
分子式:C18H13ClFN7O
分子量:397.79
纯度:98%
存储:Store at -20°C

Background:

TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39.


TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies on murine GPR39, 180 nM and 5 nM. TM-N1324 is also found to have promising in vitro ADME properties. TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0). Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%[1].



[1]. Frimurer TM, et al. Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions. J Med Chem. 2017 Feb 9;60(3):886-898.