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FTBMT
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FTBMT图片
CAS NO:1358575-02-6
规格:98%
分子量:392.35
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
FTBMT是选择性的GPR52激动剂,EC50为75nM。抗精神病和促进认知活性。
CAS:1358575-02-6
分子式:C19H16F4N4O
分子量:392.35
纯度:98%
存储:Store at -20°C

Background:

FTBMT is a selective GPR52 agonist with an EC50 of 75 nM[1]. Antipsychotic and procognitive properties[2].


FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03 6 0.04, 6.85 6 0.02, and 6.87 6 0.02[2].


FTBMT (30 mg/kg) exhibits antipsychotic-like activity without causing catalepsy in mice[2].


[1]. Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115. [2]. Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.