您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > RG7713(RO5028442)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
RG7713(RO5028442)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RG7713(RO5028442)图片
CAS NO:920022-47-5
规格:98%
分子量:437.96
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
RG7713(RO5028442)是一种高效且有选择性的脑-渗透加压素1a(V1a)受体拮抗剂,其Ki值为1nM(hV1a)和39nM(mV1a)。
CAS:920022-47-5
分子式:C25H28ClN3O2
分子量:437.96
纯度:98%
存储:Store at -20°C

Background:

RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).


RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies[1].



[1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.