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GSK121(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK121(trifluoroacetate salt)图片
CAS NO:1652591-80-4
规格:98%
分子量:501.5
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍
Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline.
CAS:1652591-80-4
分子式:C23H25N5O.CF3COOH
分子量:501.5
纯度:98%
存储:Store at -20°C

Background:

Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK121 is the initial compound identified in a screen for PAD4 inhibitors and was optimized to produce the more potent PAD4 inhibitors, GSK484 and GSK199 . GSK121 was shown to inhibit the citrullination of PAD4 target proteins in a functional assay with an IC50 value of 3.2 µM.