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(2S)-2'-Methoxykurarinone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(2S)-2'-Methoxykurarinone图片
CAS NO:270249-38-2
规格:98%
分子量:452.54
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
(2S)-2'-Methoxykurarinone 是从苦参根中分离得到的一种化合物,具有抗炎、解热、抗糖尿病和抗肿瘤作用。(2S)-2'-Methoxykurarinone 通过下调 RANKL 信号抑制破骨细胞形成和骨吸收。(2S)-2'-Methoxykurarinone 对人髓系白血病 HL-60 细胞具有细胞毒活性。
CAS:270249-38-2
分子式:C27H32O6
分子量:452.54
纯度:98%
存储:Store at -20°C

Background:

(2S)-2’-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2’-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2’-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells[1][2].




[1]. Kim JY, et al. (2S)-2’-Methoxykurarinone inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. Biol Pharm Bull. 2014;37(2):255-61. [2]. Kang TH, et al. Cytotoxic lavandulyl flavanones from Sophora flavescens. J Nat Prod. 2000 May;63(5):680-1.