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FH1(BRD-K4477)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FH1(BRD-K4477)图片
CAS NO:2719-05-3
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)282.34
FormulaC17H18N2O2
CAS No.2719-05-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 56 mg/mL (198.3 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILESCC(NC1=CC=C(CC2=CC=C(NC(C)=O)C=C2)C=C1)=O
SynonymsFH-1; NSC-12407; BRD-K4477; FH1; NSC12407; BRDK4477; FH 1; NSC 12407; BRD K4477;
实验参考方法
In Vitro

In vitro activity: In vitro, FH1(BRD-K4477) enhances hepatocyte functions, and promotes the maturation of well-differentiated cultures of iHeps, which potentially alleviates a major obstacle to the use of iPS cells as a renewable source of functional human hepatocytes.


Cell Assay: FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. It doubles albumin secretion during the differentiation of iPS cells into iHeps. Cultures treated with FH1 contain larger colonies of iHeps were with more pronounced hepatocyte morphologies. Moreover, treatment of FH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion .

In Vivo
Animal model
Formulation & Dosage
References

Nat Chem Biol. 2013 Aug;9(8):514-20.