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Nicaraven
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nicaraven图片
CAS NO:79455-30-4
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)284.31
FormulaC15H16N4O2
CAS No.79455-30-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 57 mg/mL (200.5 mM)
Water: 57 mg/mL (200.5 mM)
Ethanol: 57 mg/mL (200.5 mM)
Other info

Chemical Name: N,N'-(propane-1,2-diyl)dinicotinamide

InChi Key: KTXBOOWDLPUROC-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H16N4O2/c1-11(19-15(21)13-5-3-7-17-10-13)8-18-14(20)12-4-2-6-16-9-12/h2-7,9-11H,8H2,1H3,(H,18,20)(H,19,21)

SMILES Code: CC(NC(C1=CC=CN=C1)=O)CNC(C2=CC=CN=C2)=O

SynonymsN,N'-(propane-1,2-diyl)dinicotinamide
实验参考方法
In Vitro

In vitro activity: Nicaraven causes a dose-dependent, slight inhibition of poly (ADP-ribose) synthetase activation, possibly due to a direct inhibitory effect on the catalytic activity of poly (ADP-ribose) synthetase in RAW murine macrophages stimulated with peroxynitrite. Nicaraven partially protects against the peroxynitrite-induced suppression of mitochondrial respiration in RAW macrophages and causes a slight, dose-dependent inhibition of nitrite production in RAW macrophages stimulated with bacterial lipopolysaccharide. Nicaraven (0.35 mM) significantly inhibits the maximum aggregation rate induced by adenosine diphosphate (ADP) in the healthy volunteer platelets. Nicaraven (1.75 mM) significantly reduces the maximum aggregation rate induced by collagen in platelets. Nicaraven induces dose-dependent inhibition of platelet aggregation in both healthy volunteers and patients with cerebral thrombosis.

In VivoNicaraven inhibits lipid peroxidation in the liver of beagle dogs, improves hepatic and systemic hemodynamics and energy metabolism, and suppresses liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver. Nicaraven (20 mg/kg) elicits small reductions in infarction volume in male Sprague-Dawley rats subjected to transient focal ischemia. Nicaraven (60 mg/kg) provides significant reductions in the volume of infarction (18.6% and 20.9%) reductions for the pre- and posttreatment groups, respectively, in male Sprague-Dawley rats subjected to transient focal ischemia.
Animal model
Formulation & Dosage
References

Shock. 2000 Feb;13(2):126-34; Surgery. 2000 Jun;127(6):661-9.