| CAS NO: | 187164-19-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 354.28 |
|---|---|
| Formula | C14H9Cl2N3S2 |
| CAS No. | 187164-19-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 71 mg/mL (200.4 mM) |
| Water: <1 mg/mL | |
| Ethanol: 5 mg/mL (14.1 mM) | |
| Other info | Chemical Name: (2E)-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile InChi Key: YTAOBBFIOAEMLL-REQDGWNSSA-N InChi Code: InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1 SMILES Code: N#C/C(N1C=CN=C1)=C2SC[C@@H](C3=CC=C(Cl)C=C3Cl)S/2 |
| Synonyms | PR2699; NND502; PR 2699; NND502; PR2699; NND 502; Luzu; Lulicon |
| In Vitro | In vitro activity: Luliconazole inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 μg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 μg/ml). Luliconazole demonstrates greater potency against Trichophyton spp. |
|---|---|
| In Vivo | Luliconazole (1% cream) treatment produces a clinical effi cacy somewhat below terbinafine with 50.8% in a guinea pig model of dermatophytosis. Luliconazole (1% cream) treated guinea pigs have hairs covered with amorphous debris and a small number of conidia are detected. The improved efficacy of Luliconazole over Lanoconazole is likely due to Luliconazole being strictly an R-enantiomer while lanoconazole is a racemic mixture. |
| Animal model | Guinea pigs |
| Formulation & Dosage | 1% cream; topical |
| References | J Infect Chemother. 2004 Aug;10(4):216-9; Med Mycol. 2009;47(6):640-7; Med Mycol. 2010 May;48(3):491-7. |
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