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Luliconazole(NND 502)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Luliconazole(NND 502)图片
CAS NO:187164-19-8
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)354.28
FormulaC14H9Cl2N3S2
CAS No.187164-19-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 71 mg/mL (200.4 mM)
Water: <1 mg/mL
Ethanol: 5 mg/mL (14.1 mM)
Other info

Chemical Name: (2E)-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile

InChi Key: YTAOBBFIOAEMLL-REQDGWNSSA-N

InChi Code: InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1

SMILES Code: N#C/C(N1C=CN=C1)=C2SC[C@@H](C3=CC=C(Cl)C=C3Cl)S/2

Synonyms

PR2699; NND502; PR 2699; NND502; PR2699; NND 502; Luzu; Lulicon

实验参考方法
In Vitro

In vitro activity: Luliconazole inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 μg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 μg/ml). Luliconazole demonstrates greater potency against Trichophyton spp.

In VivoLuliconazole (1% cream) treatment produces a clinical effi cacy somewhat below terbinafine with 50.8% in a guinea pig model of dermatophytosis. Luliconazole (1% cream) treated guinea pigs have hairs covered with amorphous debris and a small number of conidia are detected. The improved efficacy of Luliconazole over Lanoconazole is likely due to Luliconazole being strictly an R-enantiomer while lanoconazole is a racemic mixture.
Animal modelGuinea pigs
Formulation & Dosage1% cream; topical
References

J Infect Chemother. 2004 Aug;10(4):216-9; Med Mycol. 2009;47(6):640-7; Med Mycol. 2010 May;48(3):491-7.