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Ipramidil(C80-1324)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ipramidil(C80-1324)图片
CAS NO:83656-38-6
规格:98%
分子量:256.26
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Ipramidil(C80-1324)是一种呋咱环化合物。在离体心脏的冠脉循环中具有显著的扩张活性。
CAS:83656-38-6
分子式:C10H16N4O4
分子量:256.26
纯度:98%
存储:Store at -20°C

Background:

Ipramidil (C80-1324) is a furoxan compound. Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.


The vasodilator action of Ipramidil (C80-1324) on coronary vessels is more potent than that of GTN and appears to be biphasic. The increase in coronary flow caused by furoxans as well as by glyceryl trinitrate (GTN) is blunted upon coinfusion of the guanylate cyclase inhibitor methylene blue. NO sign of tachyphylaxis of the vasodilator response is seen upon the repeated or continuous (60 min) application of Ipramidil at a concentration of 1 μg/mL,which induces an increase in coronary flow of 67±9% (N=5). Moreover, the vasodilatoreffect of Ipramidil is not different from control when Ipramidil is given after a 60 min preinfusion of 10 μg/mL GTN, i.e. under conditions of nitrate tolerance (P=0.493, N=3). However,when GTN is applied after a 30 min infusion of Ipramidil, its dilator response is significantly diminished (P=0.006, N=3). Unlike GTN, Ipramidil concentration independently increases the spontaneous beating rate of the hearts by 10-30 beats per minute and appeared to have a weak positive inotropic effect[1].



[1]. Feelisch M, et al. Thiol-mediated generation of nitric oxide accounts for the vasodilator action of furoxans. Biochem Pharmacol. 1992 Sep 25;44(6):1149-57.