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15(R)-15-methyl Prostaglandin D2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
15(R)-15-methyl Prostaglandin D2图片
CAS NO:210978-26-0
规格:98%
分子量:366.5
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2.
CAS:210978-26-0
分子式:C21H34O5
分子量:366.5
纯度:98%
存储:Store at -20°C

Background:

15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1 and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.