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Funalenone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Funalenone图片
CAS NO:259728-61-5
规格:98%
分子量:288.3
包装与价格:
包装价格(元)
500ug电议
1mg电议
2.5mg电议

产品介绍
Funalenone is a phenalenone originally isolated from A.
CAS:259728-61-5
分子式:C15H12O6
分子量:288.3
纯度:98%
存储:Store at -20°C

Background:

Funalenone is a phenalenone originally isolated from A. niger. It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 μM). Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM. It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 μg/mL.