GSK2018682是一种S1P1和S1P5receptor的激动剂，pEC50值分别为7.7和7.2，对S1P2,S1P3或S1P4没有明显的激动活性，可用于多发性硬化的研究。
CAS：1034688-30-6
分子式：C22H21ClN4O4
分子量：440.88
纯度：98%
存储：Store at -20°C

Background:

GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.

GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4[1].

[1]. Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3(3):170-8.