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Flopropione
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flopropione图片
CAS NO:2295-58-1
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)182.17
FormulaC9H10O4
CAS No.2295-58-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 36 mg/mL (197.61 mM)
Water: <1 mg/mL
Ethanol: 36 mg/mL (197.61 mM)
SMILESCCC(C1=C(O)C=C(O)C=C1O)=O
SynonymsArgobyl; Chlonarin; Cospanon; Ecapron; Flopion; Flopropion; Gallepronin; Gasstenon; Labroda
实验参考方法
In Vitro

In vitro activity: Flopropione at temperatures below its T(g) shows no Lorentzian relaxation. Flopropione at temperatures below its T(g) has higher molecular mobility than Nifedipine. Flopropione shows Arrhenius temperature dependence throughout the entire temperature range and extrapolation of tau (beta) measured above T (g) by dielectric relaxation agreed with tau (beta) measured below T (g) by TAM/MDSC.

In VivoThe effect of Flopropione as an antispasmodic agent on the rate of passing a calculus from the urinary tract has been compared retrospectively with patients in whom passage was spontaneous. Flopropine has been shown, with statistical significance, to be superior to the control in cumulative passage rate after initiation of administration. Flopropine has been shown to exert a spasmolytic effect not only on smooth muscle of the gastrointestinal tract but also on smooth muscle of the pancreatobiliary and urinary systems.
Animal model
Formulation & Dosage
References

J Pharm Sci. 2000 Mar;89(3):408-16; Pharm Res. 2006 Oct;23(10):2277-90.