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Dibutyryl-cAMP,sodium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dibutyryl-cAMP,sodium salt图片
CAS NO:16980-89-5
包装:10mg
规格:98%
市场价:794元
分子量:491.37

产品介绍
Cell-permeable cAMP analog that activates cAMP-dependent protein kinases
CAS:16980-89-5
分子式:C18H23N5NaO8P
分子量:491.37
纯度:98%
存储:Store at -20°C

Background:

Bucladesine sodium salt (Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP) is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine sodium salt acts as a phosphodiesterase (PDE) inhibitor.


参考文献:
[1]. Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20.
[2]. Azami, K., et al., The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in rats. Eur J Pharmacol, 2010. 636(1-3): p. 102-7.
[3]. Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43.
[4]. Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.
[5]. Salehi F, et al. Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain. Fundam Clin Pharmacol. 2017 Aug;31(4):411-419.