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Sulfamethoxypyridazine(CL13494)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sulfamethoxypyridazine(CL13494)图片
CAS NO:80-35-3
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
5g电议
10g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)280.3
FormulaC11H12N4O3S
CAS No.80-35-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 56 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info
Chemical Name: Benzenesulfonamide, 4-amino-N-(6-methoxy-3-pyridazinyl)-
InChi Key: VLYWMPOKSSWJAL-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)
SMILES Code: O=S(C1=CC=C(N)C=C1)(NC2=NN=C(OC)C=C2)=O
SynonymsCL 13494; CL 13494; CL13494; Lisulfen; Longin; Medicel; Midicel; Midikel; Myasul;
实验参考方法
In Vitro

In vitro activity: Sulfamethoxypyridazine is found to be highly effective in a preliminary study of P. carinii-infected rats. Sulfamethoxypyridazine is also found to be as effective as sulfamethoxazole in P. carinii-infected rats at 1 mg/kg of body weight/day. Sulfamethoxypyridazine is effective aganist a murine model of P. carinii with ED50s of 0.06 mg/kg/day and 0.08 mg/kg/day as determined by the Giemsa and silver stain scores, respectively. Sulfamethoxypyridazine at either 0.1 mg/kg/day or 0.3 mg/kg/day is found to be significantly more effective than sulfamethoxazole at 0.47 mg/kg/day) aganist a murine model of P. carinii. Sulfamethoxypyridazine exhibits the biological half lives of 11.0 hours and 13.7 hours following im and sc administration, respectively, in goats. Sulfamethoxypyridazine exhibits the systemic availabilities of 68.6% and 58.7% following im and sc administration, respectively, in goats. Sulfamethoxypyridazine exhibits the distribution and elimination half life of 0.1 hour and 6.28 hours, respectively, in goats. Sulfamethoxypyridazine exhibits the values of apparent volume of distribution at steady state and total body clearance of 0.39 mL/kg/min and 0.73 mL/kg/min, respectively, in goats.

In Vivo
Animal model
Formulation & Dosage
ReferencesAntimicrob Agents Chemother. 1998 Apr;42(4):934-5; Vet Res. 1997;28(1):101-4; Rev Elev Med Vet Pays Trop. 1994;47(2):215-8.