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Substance P 1-7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Substance P 1-7图片
CAS NO:68060-49-1
规格:98%
分子量:900.04
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Substance P (7-11) 是神经肽P物质 (SP) 的片段。Substance P (7-11) 可对孤束核产生抑制和缓和作用。
CAS:68060-49-1
分子式:C41H65N13O10
分子量:900.04
纯度:98%
存储:Store at -20°C

Background:

Substance P (7-11) is a fragment of the neuropeptide, substance P (SP). Substance P (7-11) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.



Substance P (7-11) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (7-11) is an endogenous modulator of SP actions[1]. Injection of low doses of Substance P (7-11) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord[2].


[1]. Herrera-Marschitz M, et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521(1-2):316-20. [2]. Sakurada T, et al. Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95(1-3):281-5.