Proadrenomedullin (45-92), human 是肾上腺髓质素原 (MR-proADM) 的中间区域片段，包括肾上腺髓质素原前体 (pre-proADM) 的 45-92 个氨基酸。Proadrenomedullin (45-92), human 半衰期更长且相对稳定，与肾上腺髓质素 (ADM) 等摩尔量生成，使其成为肾上腺髓质素基因产物血浆水平的替代指标。
CAS：166798-69-2
分子式：C215H359N67O73S2
分子量：5114.76
纯度：98%
存储：Store at -20°C

Background:

Proadrenomedullin (45-92), human, a mid-regional fragment of proadrenomedullin (MR-proADM), comprises amino acids 45-92 of pre-proADM. Proadrenomedullin (45-92), human has a longer half-life, is relatively stable and is produced in equimolar amounts to adrenomedullin (ADM), making it a surrogate for plasma levels of ADM gene products[1][2].

[1]. Lorubbio M, et al. Midregional pro-adrenomedullin (MR-ProADM) reference values in serum. Clin Biochem. 2018 Mar;53:173-174. [2]. Al-Omari MA, et al. Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in African Americans with hypertension. Am J Hypertens. 2009 Aug;22(8):860-6.